Cross reactivity between Trypanosoma cruzi and Leishmania antigens in the lymphocyte blastogenesis assay.
نویسندگان
چکیده
The in vitro blastogenesis response of lymphocytes from 19 patients, with either visceral or mucocutaneous leishmaniasis or Chagas disease, to antigens of the Leishmania-Trypanosoma complex was studied. Cells from all patients responded to both homologous and heterologous antigens and the magnitude of the responses did not differ for any of the patient groups or antigens.
منابع مشابه
Immunochemical characterization of antigens with serological cross-reactivity in trypanosomes
Trypanosomatidae is a group of protozoa belonging to Trypanosomatida order, where the genres of medical importance Leishmania and Trypanosoma are inserted. These genres include parasites Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei, etiologic agents of leishmaniasis, Chagas disease and sleeping sickness, respectively classified as Neglected Tropical Diseases (NTDs) by the World Hea...
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Serological diagnosis of Trypanosoma cruzi infection is hampered by issues related to test specificity due to the cross-reactivity of most antigens with proteins of related parasites such as Leishmania spp. The recombinant calflagins are considered relevant antigens for the diagnosis of infection by Trypanosoma cruzi. In the present work, we describe two genes coding for putative calflagins in ...
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Five commercially available enzyme-linked immunosorbent assays (ELISAs), one in-house ELISA, and two hemagglutination assays were evaluated to determine their diagnostic accuracy for Chagas' disease in two studies. In study 1, ELISA kits showed 100% sensitivity, but specificities ranged from 82.84% to 100% when leishmaniasis cases were included and from 95.57% to 100% when leishmaniasis cases w...
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عنوان ژورنال:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
دوره 81 1 شماره
صفحات -
تاریخ انتشار 1987